The toxicity associated with nickel (II) and chromium (VI) is mainly due to generation of reactive oxygen species (ROS) with subsequent oxidative deterioration of biological macromolecules.Both nickel and chromium can generate free radicals (FR) directly from molecular oxygen in a two step process to produce superoxide anion and in Power Plug Adaptors continued process, produce highly toxic hydroxyl radical.The pro-oxidative effects are compounded by fact that they also inhibit antioxidant enzymes and deplete intracellular glutathione.
Garlic (Allium sativum) has played an important dietary and medicinal role throughout the history of mankind.Garlic has the potential to enhance the endogenous antioxidant status in nickel as well Shrubs as hexavalent chromium induced lipid peroxidation in normal and diabetic rats.